AG Biochemische Ökologie und Molekulare Evolution

Publikationen (Wissenschaft)

Hier finden Sie eine Übersicht der wissenschaftlichen Veröffentlichungen.

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Publikationen aus dem Bereich des Botanischen Gartens werden gesondert gelistet.


  • Kruse, L., Stegemann, T., Sievert, C., Ober, D. (2017). Identification of a second site of pyrrolizidine alkaloid biosynthesis in Comfrey to boost plant defense in floral stage. Plant Physiology, 174: 47-55. PMID: 28275146, . This article is dedicated to Thomas Hartmann (Braunschweig, Germany) on the occasion of his 80th birthday.
  • Boraginales Working Group - Luebert, F., Cecchi, L., Frohlich, M. W., Gottschling, M., Guilliams, C. M., Hilger, H. H., Hasenstab-Lehman, K. E., Miller, J. s., Mittelbach, M., Nazaire, M., Nepi, M., Nocentini, D., Ober, D., Olmstead, R. G., Selvi, F., Simpson, M. G., Sutorý, K., Valdés, B., Walden, G. K., Weigend, M. (2016). Familial Classification of the Boraginales. Taxon, 65 (3): 502-522. DOI: 10.12705/653.5
  • Ober, D. (2016). Phytochemistry of the Boraginales. Part of: Weigend, M., Selvi, F., Thomas, D. C., Hilger, H. H. "Boraginaceae". In: Flowering Plants. Eudicots. Aquifoliales, Boraginales, Bruniales, Dipsacales, Escalloniales, Garryales, Paracryphiales, Solanales (except Convolvulaceae), Icacinaceae, Metteniusaceae, Vahliaceae, Ed. Kadereit, Joachim W., Bittrich, V., Vol. 15, Springer: 55-57. [further information]
  • Krossa, S., Faust, A., Ober, D., Scheidig, A. (2016). Comprehensive structural characterization of the bacterial homospermidine synthase - an essential enzyme of the polyamine metabolism. Scientific Reports, 6: 19501.  PMID: 26776105, DOI: 10.1038/srep19501
  • Kaltenegger, E., Ober, D. (2015). Paralogue interference affects the dynamics after gene duplication. Trends in Plant Science, 20: 814-821. PMID: 26638775, DOI: 10.1016/j.tplants.2015.10.003
  • Sievert, C., Beuerle, T., Hollmann, J., Ober, D. (2015). Single cell subtractive transcriptomics for identification of cell-specifically expressed candidate genes of pyrrolizidine alkaloid biosynthesis. Phytochemistry, 117: 17-24. PMID: 26057225, DOI: 10.1016/j.phytochem.2015.05.003
  • Geilfus, C.-M., Ober, D., Eichacker, L. A., Mühling, K. H., Zörb, C. (2015). Down regulation of ZmEXPB6 is correlated with salt mediated growth reduction in leaves of Zea mays L. J. Biol. Chem., 290: 11235-11245. Pubmed 25750129, DOI: 10.1074/jbc.M114.619718
  • Irmer, S., Podzun, N., Langel, D., Heidemann, F., Kaltenegger, E., Schemmerling, B., Geilfus, C.-M., Zörb, C., Ober, D. (2015). A new aspect of plant-rhizobia interaction - alkaloid biosynthesis in Crotalaria depends on nodulation. Proc. Natl. Acad. Sci. U.S.A., 112: 4164-4169. Pubmed, DOI: 10.1073/pnas.1423457112
  • Kaltenegger, E., Eich, E., Ober, D. (2013). Evolution of homospermidine synthase in the Convolvulaceae – a story of gene duplication, gene loss, and periods of various selection pressures. Plant Cell, 25: 1213-1227 PubMed, , OpenAccess
  • Niemüller, D., Reimann, A., Ober, D. (2012). Distinct cell-specific expression of homospermidine synthase involved in pyrrolizidine alkaloid biosynthesis in three species of the Boraginales. Plant Physiology, 159: 920-929. PubMed, DOI:10.1104/pp.112.195024, OpenAccess
  • Wang, L., Beuerle, T., Timbilla, J., Ober, D. (2012). Independent recruitment of a flavin-dependent monooxygenase for safe accumulation of sequestered pyrrolizidine alkaloids in grasshoppers and moths. PLoS ONE 7: e31796. PubMed, DOI:10.1371/journal.pone.0031796
  • Langel, D., Ober, D. (2011). Evolutionary recruitment of a flavin-dependent monooxygenase for stabilization of sequestered pyrrolizidine alkaloids in arctiids. Phytochemistry, 72: 1576-1584. PubMed, DOI: 10.1016/j.phytochem.2010.12.014
  • Langel, D., Ober, D., Pelser, P. (2010). The evolution of pyrrolizidine alkaloid biosynthesis and the diversity in the Senecioneae. Phytochemistry Reviews, 10(1): 3-74. DOI: 10.1007/s11101-010-9184-y
  • Sehlmeyer, S., Wang, L., Langel, D., Heckel, D.G., Mohagheghi, H., Petschenka, G., Ober, D. (2010). Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (Lepidoptera). PLoS ONE 5(5): e10435 PubMed, DOI:doi:10.1371/journal.pone.0010435
  • Ober, D. (2010). Gene duplications and the time thereafter - examples from plant secondary metabolism. Plant Biology,12: 570-577. PubMed
  • Abdelhady, M. I. S., Beuerle, T., Ober, D. (2009). Homospermidine in transgenic tobacco results in considerably reduced spermidine levels but is not converted to pyrrolizidine alkaloid precursors. Plant Molecular Biology, 71: 145-155 PubMed
  • Ober, D., Kaltenegger, E. (2009). Pyrrolizidine alkaloid biosynthesis, evolution of a pathway in plant secondary metabolism. Phytochemistry, 70: 1687-1695 PubMed
  • Nurhayati; N., Gondé, D., Ober, D. (2009). Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: Identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes. Phytochemistry, 70: 508-516 PubMed
  • Bilger, W., Dauborn, B., Ober, D. (2009). Sekundärstoffwechsel. In: Taschenbuch Biologie - Botanik, Munk, K. (Ed.),  Thieme , Stuttgart: 359-401. [Additional Information]
  • Anke, S., Gondé, D., Kaltenegger, E., Hänsch, R., Theuring, C., Ober, D. (2008). Pyrrolizidine alkaloid biosynthesis in Phalaenopsis orchids: Developmental expression of alkaloid-specific homospermidine synthase in root tips and young flower buds. Plant Physiology 148 : 751-760. PubMed
  • Michalski, C., Mohagheghi, H., Nimtz, M., Pasteels, J., Ober, D. (2008). Salicyl alcohol oxidase of the chemical defense secretion of two chrysomelid leaf beetles: Molecular and functional characterization of two new members of the GMC oxidoreductase gene family. J. Biol. Chem. 283 : 19219-19228. PubMed
  • Hartmann, T. , Ober, D. (2008). Defense by Pyrrolizidine Alkaloids: Developed by Plants and Recruited by Insects. In: "Induced Plant Resistance to Herbivory", Schaller, A. (Ed.), Springer Science+Business Media B.V.: 213-231. Additional Information
  • Ober, D. (2007). Keine Wunderwaffe aus dem Regenwald! In: "Vorbild Natur. Stand und Perspektiven der Naturstoff-Forschung in Deutschland", DECHEMA, Frankfurt/M. [pdf]
  • Ober, D. (2007). Pflanzenextrakte als Arzneimittel? In: "Vorbild Natur. Stand und Perspektiven der Naturstoff-Forschung in Deutschland", DECHEMA, Frankfurt/M. [pdf]  
  • Frölich, C., Ober, D., Hartmann, T. (2007). Tissue distribution, core biosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species. Phytochemistry 68 : 1026-1037. PubMed
  • Frölich, C., Hartmann, T., Ober, D. (2006). Tissue distribution and biosynthesis of 1,2-saturated pyrrolizidine alkaloids in Phalaenopsis hybrides (Orchidaceae). Phytochemistry 67 : 1493-1502. PubMed]
  • Ober, D. (2005). Seeing double – gene duplication and diversification in plant secondary metabolism. Trends Plant Sci. 10 : 444-449. PubMed
  • Nurhayati, N., Ober, D. (2005). Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: does Crotalaria possess a functional HSS that still has DHS activity? Phytochemistry 66 : 1346-1357. PubMed
  • Anke, S., Niemüller, D., Moll, S., Hänsch, R., Ober, D. (2004). Polyphyletic origin of pyrrolizidine alkaloids within the Asteraceae: Evidence from differential tissue expression of homospermidine synthase. Plant Physiology 136 : 4037-4047. PubMed
  • Reimann, A., Nurhayati, N., Backenköhler, A., and Ober, D. (2004). Repeated evolution of the pyrrolizidine-mediated defense system in separate angiosperm lineages. Plant Cell 16 : 2772-2784. PubMed
  • Ober, D. (2003). Chemical ecology of alkaloids exemplified with the pyrrolizidines. Recent Adv. Phytochem. (J. T. Romeo et al., eds., Pergamon, Amsterdam) 37, : 203-230.
  • Ober, D., Harms, R., Witte, L., Hartmann, T. (2003). Molecular evolution by change of function: Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein. J. Biol. Chem. 278 : 12805-12812. PubMed
  • Ober, D., Gibas, L., Witte, L., Hartmann, T. (2003). Evidence for general occurrence of homospermidine in plants and its supposed origin as by-product of deoxyhypusine synthase. Phytochemistry 62 : 339-344. PubMed
  • Hartmann,T., Ober,D. (2003). Der pflanzliche Sekundärstoffwechsel: Biologische Notwendigkeit und pharmazeutischer Nutzen. Carolo-Wilhelmina: Forschungsmagazin der Technischen Universität Braunschweig 38 : 26-32 pdf
  • Moll, S. ,Anke, S., Kahmann, U., Hansch, R., Hartmann, T., Ober, D. (2002). Cell-specific expression of homospermidine synthase, the entry enzyme of the pyrrolizidine alkaloid pathway in Senecio vernalis, in comparison with its ancestor, deoxyhypusine synthase. Plant Physiology 130 : 47-57. PubMed
  • Naumann, C., Hartmann, T., Ober, D. (2002). Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae. Proc. Natl. Acad. Sci. U.S.A. 99 : 6085-90 PubMed
  • Ober, D. (2001). Warum gibt es Gift- und Arzneipflanzen? Die Evolution des pflanzlichen Sekundärstoffwechsels am Beispiel der Pyrrolizidin-Alkaloide. Deutsche Apotheker Zeitung 141 : 2127-2131.
  • Ober, D., Hartmann, T. (2000). Phylogenetic origin of a secondary pathway: The case of pyrrolizidine alkaloids. Plant Mol. Biol. 44 : 445-450. PubMed
  • Ober, D., Harms, R., Hartmann, T. (2000). Cloning and expression of homospermidine synthase from Senecio vulgaris: A revision. Phytochemistry 55 : 305-309. PubMed
  • Hartmann, T., Ober, D. (2000). Biosynthesis and metabolism of pyrrolizidine alkaloids in plants and specialized insect herbivores. Top. Curr. Chem. 209 : 207-244.
  • Ober, D., Hartmann, T. (1999). Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase. Proc. Natl. Acad. Sci. U.S.A. 96 : 14777-14782. PubMed
  • Ober, D., Hartmann, T. (1999). Deoxyhypusine synthase from tobacco: cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity. J. Biol. Chem. 274 : 32040-32047. PubMed
  • Tholl, D., Ober, D., Martin, W., Kellermann, J., Hartmann, T. (1996). Purification, molecular cloning and expression in Escherichia coli of homospermidine synthase from Rhodopseudomonas viridis. Eur. J. Biochem. 240 : 373-379 PubMed
  • Ober, D.,Tholl, D.,Martin, W.,Hartmann, T. (1996). Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli. J. Gen. Appl. Microbiol. 42 : 411-419.
  • Böttcher, F., Ober, D., Hartmann, T. (1994). Biosynthesis of pyrrolizidine alkaloids: Putrescine and spermidine are essentail substrates of enzymatic homospermidine formation. Can. J. Chem. 72 : 80-85.